Hypermethylation of the

Authors :: Linlin, Liu
Xiaopei, Yang
Fei, Zhao
Changqing, Gao
Ning, Zhang
Jianjun, Bao
Kuan, Li
Xulan, Zhang
Xiaoxiao, Lu
Ye, Ruan
Shurong, Zhong
Source :: The American journal of drug and alcohol abuse. 47(6)
Publication Year :: 2021
Abstract: Alcohol use disorder (AUD) is one of the most serious public health problems worldwide. TheTo investigate whether methylation patterns ofDNA methylation of theIn the AUD group, compared with the control group, OPRM1 was hypermethylated(p.01) but there was no significant difference in the methylation level of ALDH2 (p.05). 9 CpG sites of OPRM1 (p.05) and 2 CpG sites of ALDH2 (p.01) were hypermethylated. Smoking promoted AUD-mediated hypermethylation ofOur study demonstrates that DNA hypermethylation of the