[Impaired free radical oxidation and structural-functional state of erythrocytes in chronic respiratory insufficiency and a method of their correction]

To examine erythrocytic structural and functional changes and lipid peroxidation impairments, which are caused by respiratory failure, and to study whether small-volume extracorporeal blood membrane gas exchange (SVEBMGE) can correct these disorders, a clinical and experimental studies were undertaken to examine 15 patients with tuberculosis complicated by Degree III respiratory failure. Respiratory failure was found to activate lipid peroxidation which was accompanied by lower blood antioxidative activity and correlated with the structural and functional changes of red blood cells and their population composition. The application of SVEBMGE to correct experimental hypoxemia in Degree III respiratory failure complicating pulmonary tuberculosis was demonstrated to normalize the population composition of red blood cells showed the substituting and antioxidant-stimulating effect of oxygen, by contributing to a reduction in the rate of free radical oxidation.