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Poloxamer micellar system for intra-articular injection of 15-deoxy
- Source :
- International journal of pharmaceutics. 583
- Publication Year :
- 2020
-
Abstract
- Painful conditions of the temporomandibular joint (TMJ) are challenging to manage and most attempts often result in unsatisfactory outcomes. In such context, nanocarrier systems, such as polymeric micelles, have been showing encouraging results in solving therapeutic limitations. Poloxamers are widely used, especially PL 407, because of their high biocompatibility and approval by the Food and Drug Administration (FDA) for clinical use. 15-deoxy
- Subjects :
- Male
Drug Carriers
Temporomandibular Joint
Prostaglandin D2
Drug Compounding
Anti-Inflammatory Agents
Biological Availability
Poloxamer
Temporomandibular Joint Disorders
Arthralgia
Injections, Intra-Articular
Chemotaxis, Leukocyte
Disease Models, Animal
Formaldehyde
Leukocytes
Animals
Cytokines
Tissue Distribution
Inflammation Mediators
Rats, Wistar
Micelles
Subjects
Details
- ISSN :
- 18733476
- Volume :
- 583
- Database :
- OpenAIRE
- Journal :
- International journal of pharmaceutics
- Accession number :
- edsair.pmid..........4466b3a77066767bad08a37748313cf8