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CRH stimulation improves
- Source :
- Endocrine. 65(1)
- Publication Year :
- 2019
-
Abstract
- In MRI-negative cases Cushing's disease (CD), surgeons perform a more extensive exploration of the pituitary gland, with fewer instances of hormonal remission.Subjects with a likely diagnosis of CD (n = 27, 20 females) each underwent twoThe mean-SUV of adenomas was significantly increased from baseline (3.6 ± 1.5) with oCRH administration (3.9 ± 1.7; one-tailed p = 0.003). Neuroradiologists agreed that adenomas were visible on 21 scans, not visible on 26 scans (disagreed about 7, kappa = 0.7). oCRH-stimulation led to the detection of additional adenomas (n = 6) not visible on baseline-PET study. Of the MRI-negative adenomas (n = 5), two were detected on PET imaging (one only after oCRH-stimulation). USP8 mutations or glycolytic pathway proteins were not associated with SUV in corticotropinomas.The results of the current study suggest that oCRH-stimulation may lead to increased
Details
- ISSN :
- 15590100
- Volume :
- 65
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Endocrine
- Accession number :
- edsair.pmid..........43f2eacd02ae1afed6da05bc20c6ae2f