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Association of the Neprilysin gene with susceptibility to late-onset Alzheimer's disease
- Source :
- Dementia and geriatric cognitive disorders. 17(3)
- Publication Year :
- 2003
-
Abstract
- Neprilysin (NEP), also known as neutral endopeptidase, enkephalinase, CD 10, and common acute lymphoblastic leukemia antigen, is a 97-kD protein. NEP can degrade amyloid beta peptides, and its mRNA and protein levels are known to be reduced in the brains of patients with Alzheimer's disease (AD), making the NEP gene a substantial candidate for an AD risk factor. We examined the genetic association of three NEP polymorphisms, a GT-repeat polymorphism and two single nucleotide polymorphisms (SNPs, -1075AG and -1284GC) in its promoter region, with AD in a Japanese case-control sample (240 patients and 163 controls). The GT-repeat polymorphism, but not the SNPs, was significantly associated with late-onset AD (p = 0.0007). Our findings suggest that the GT-repeat polymorphism in the promoter region of the NEP gene or some other unknown polymorphisms, which are in a linkage disequilibrium, confer a susceptibility to late-onset AD.
- Subjects :
- Male
Polymorphism, Genetic
Genotype
Transcription, Genetic
Genetic Linkage
Reverse Transcriptase Polymerase Chain Reaction
Down-Regulation
DNA
Polymorphism, Single Nucleotide
Apolipoproteins E
Gene Frequency
Alzheimer Disease
Case-Control Studies
Humans
Female
Neprilysin
RNA, Messenger
Age of Onset
Promoter Regions, Genetic
Alleles
Aged
Subjects
Details
- ISSN :
- 14208008
- Volume :
- 17
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Dementia and geriatric cognitive disorders
- Accession number :
- edsair.pmid..........43effe0a8480d4808ea549eccc1bea71