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Impact of prior infection status on antibody response to the BNT162b2 mRNA COVID-19 vaccine in healthcare workers at a COVID-19 referral hospital in Milan, Italy

Authors :
Laura, Milazzo
Laura, Pezzati
Letizia, Oreni
Cristina, Kullmann
Alessia, Lai
Arianna, Gabrieli
Giovanna, Bestetti
Cristian, Beschi
Federico, Conti
Cosimo, Ottomano
Cristina, Gervasoni
Luca, Meroni
Massimo, Galli
Spinello, Antinori
Anna Lisa, Ridolfo
Source :
Human vaccinesimmunotherapeutics. 17(12)
Publication Year :
2022

Abstract

In Italy, SARS-CoV-2 vaccination campaign prioritized healthcare workers (HCWs) to receive two doses of BNT162b2 vaccine, irrespective of a previous SARS-CoV-2 infection. In this real-life study, we compared the humoral response to BNT162b2 vaccine in HCWs with and without a previous SARS-CoV-2 infection. Of the 407 HCWs enrolled, 334 (82.1%) were SARS-CoV-2-naive and 73 (17.9%) SARS-CoV-2-experienced. Post-vaccine humoral response was detectable in more than 98% of HCWs. Overall, the median level of anti-S IgG in SARS-COV-2-experienced HCWs was twice as high as those of SARS-CoV-2-naive subjects (24641.0 AU/mL [IQR: 15273.0-40000.0] versus 13053.8 [IQR: 7303.3-20105.8]

Details

ISSN :
2164554X
Volume :
17
Issue :
12
Database :
OpenAIRE
Journal :
Human vaccinesimmunotherapeutics
Accession number :
edsair.pmid..........40134c9ed29ed0ae96c43e2fab82e408