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Impact of prior infection status on antibody response to the BNT162b2 mRNA COVID-19 vaccine in healthcare workers at a COVID-19 referral hospital in Milan, Italy
- Source :
- Human vaccinesimmunotherapeutics. 17(12)
- Publication Year :
- 2022
-
Abstract
- In Italy, SARS-CoV-2 vaccination campaign prioritized healthcare workers (HCWs) to receive two doses of BNT162b2 vaccine, irrespective of a previous SARS-CoV-2 infection. In this real-life study, we compared the humoral response to BNT162b2 vaccine in HCWs with and without a previous SARS-CoV-2 infection. Of the 407 HCWs enrolled, 334 (82.1%) were SARS-CoV-2-naive and 73 (17.9%) SARS-CoV-2-experienced. Post-vaccine humoral response was detectable in more than 98% of HCWs. Overall, the median level of anti-S IgG in SARS-COV-2-experienced HCWs was twice as high as those of SARS-CoV-2-naive subjects (24641.0 AU/mL [IQR: 15273.0-40000.0] versus 13053.8 [IQR: 7303.3-20105.8]
Details
- ISSN :
- 2164554X
- Volume :
- 17
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Human vaccinesimmunotherapeutics
- Accession number :
- edsair.pmid..........40134c9ed29ed0ae96c43e2fab82e408