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Radiochemical synthesis and preclinical evaluation of
- Source :
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 128
- Publication Year :
- 2018
-
Abstract
- A new renaissance started in the research and application of cyclodextrins a few years ago. 2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is used in the formulation of drugs and recently orphan designation was granted for the treatment of Niemann-Pick disease, type C. HPBCD is considered to be safe, but the exact mechanism of action and side effects are not completely explained. Labeled cyclodextrin derivatives are required to reveal the biological activity and in vivo distribution by imaging techniques. The aims of our study were to synthetize the
Details
- ISSN :
- 18790720
- Volume :
- 128
- Database :
- OpenAIRE
- Journal :
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
- Accession number :
- edsair.pmid..........3e7842da443a0ae77ee12cc7dbbf13ae