Studies on HBcAg-rBlo t 5-21 Fusion Protein Vaccine That Alleviates

In tropical and subtropical areas, allergens from the dust mite speciesTo generate a chimeric virus-like particle containing HBcAg, Blo t 5 and Blo t 21 that can treat allergies caused by To produce allergic asthma in mice, prokaryotic expression and purification ofIn allergy-induced mouse model experiments, the fusion allergen rBlo t 5-21 was more effective than the individual allergens rBlo t 5 and rBlo t 21 at inducing allergy. We found that vaccinating allergic mice with the recombinant fusion protein vaccine HBcAg-rBlo t 5-21 alleviated allergy symptoms elicited by the rBlo t 5-21 allergen. Vaccination with HBcAg-rBlo t 5-21 resulted in a decrease in total serum IgE levels, suppression of anaphylaxis, and reduction of inflammatory cell infiltration into lung tissue as compared to the PBS group.HBcAg-rBlo t 5-21, a protein vaccine containing both the hepatitis B core antigen and the