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Physiologic colonic uptake of

Authors :
Lena, Cvetkovic
Claudine, Régis
Corentin, Richard
Lisa, Derosa
Antoine, Leblond
Julie, Malo
Meriem, Messaoudene
Antoine, Desilets
Wiam, Belkaid
Arielle, Elkrief
Bertrand, Routy
Daniel, Juneau
Source :
European journal of nuclear medicine and molecular imaging. 48(5)
Publication Year :
2020

Abstract

Immune checkpoint inhibitors (ICI) represent the backbone treatment for advanced non-small cell lung cancer (NSCLC). Emerging data suggest that increased gut microbiome diversity is associated with favorable response to ICI and that antibiotic-induced dysbiosis is associated with deleterious outcomes.Seventy-one patients with advanced NSCLC who underwent a PET/CT prior to ICI were identified. Blinded colonic contouring was performed for each colon segment and patients were stratified according to the median of the average colon SUVThe high colon SUVLower colon physiologic

Details

ISSN :
16197089
Volume :
48
Issue :
5
Database :
OpenAIRE
Journal :
European journal of nuclear medicine and molecular imaging
Accession number :
edsair.pmid..........3c860802266e7f4309872c1c636d16a3