Back to Search
Start Over
Immunostimulating Effects of Extract of Acanthopanax sessiliflorus
- Source :
- Experimental Animals
- Publication Year :
- 2013
- Publisher :
- Japanese Association for Laboratory Animal Science, 2013.
-
Abstract
- As malfunction/absence of immune cells causes a variety of immunosuppressive disorders and chemical synthetic drugs for curing these diseases have many adverse effects, vigorous studies are being conducted. The Acanthopanax family has been used as traditional medicines for gastric ulcer, diabetes, etc. and culinary materials in East-South Asia. In this study, the immunostimulating properties of A. sessiliflorus were evaluated. A. sessiliflorus increased not only the splenocyte number but also immune-related cytokines such as TNF-α. However, it could not upregulate the expressions of IFN-γ and IL-2. A. sessiliflorus increased the swimming time, and comparison of organ weights relative to body weights for immune-related organs such as the spleen and thymus after a forced swim test showed that it could recover the spleen and thymus weights. It also increased the expression of TNF-α and slightly increased the concentration of IFN-γ but not IL-2. From the results, we concluded that as A. sessiliflorus has not only a host defense effect but also a stress-ameliorating property, further study it will be a promising material of immunostimulating material.
- Subjects :
- Male
Plants, Medicinal
Original
Plant Extracts
Tumor Necrosis Factor-alpha
immunostimulating
Eleutherococcus
Organ Size
Thymus Gland
Rats
Up-Regulation
Rats, Sprague-Dawley
Interferon-gamma
Adjuvants, Immunologic
Stress, Physiological
TNF-α
Acanthopanax sessiliflorus
Animals
Interleukin-2
rat
IFN-γ
Spleen
Swimming
Cell Proliferation
Subjects
Details
- Language :
- English
- ISSN :
- 18817122 and 13411357
- Volume :
- 62
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Experimental Animals
- Accession number :
- edsair.pmid..........3aea43c66cda5cc97555571878c96be4