Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P

Authors :: Haruto, Kurata
Kensuke, Kusumi
Kazuhiro, Otsuki
Ryo, Suzuki
Masakuni, Kurono
Takaki, Komiya
Hiroshi, Hagiya
Hirotaka, Mizuno
Hiroki, Shioya
Takeji, Ono
Yuka, Takada
Tatsuo, Maeda
Norikazu, Matsunaga
Tetsu, Kondo
Sachiko, Tominaga
Ken-Ici, Nunoya
Hidekazu, Kiyoshi
Masaharu, Komeno
Shinji, Nakade
Hiromu, Habashita
Source :: Journal of medicinal chemistry. 60(23)
Publication Year :: 2017
Abstract: The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine-3-carboxylic acid 13n (ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P

Subjects :: Male
Mice, Inbred BALB C
Administration, Oral
CHO Cells
Naphthalenes
Autoimmune Diseases
Rats, Sprague-Dawley
Macaca fascicularis
Mice
Receptors, Lysosphingolipid
Cricetulus
Rats, Inbred Lew
Animals
Azetidines
Humans
Female
Lymphocytes

Tools