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Chromosome Translocation t(14;21)(q11;q22) Activates Both
- Source :
- Cancer genomicsproteomics. 17(1)
- Publication Year :
- 2019
-
Abstract
- Background/Aim: The chromosome translocation t(14;21)(q11;q22) was reported in four pediatric T-cell lymphoblastic leukemias and was shown to activate the OLIG2 gene. Materials and Methods: A pediatric T-cell lymphoblastic lymphoma was investigated using G-banding chromosome analysis, fluorescence in situ hybridization (FISH), and immunocytochemistry. Results: The malignant cells carried a t(14;21)(q11;q22) aberration. The translocation moves the enhancer elements of TRA/TRD from band 14q11 to 21q22, a few thousands kbp downstream of OLIG1 and OLIG2, resulting in the production of both OLIG1 and OLIG2 proteins. Conclusion: The translocation t(14;21)(q11;q22) occurs in some pediatric T-cell lymphoblastic malignancies. Activation of both OLIG1 and OLIG2 by t(14;21)(q11;q22) in T-lymphoblasts and the ensuing deregulation of thousands of genes could explain the highly malignant disease and resistance to treatment that has characterized this small group of patients.
- Subjects :
- Chromosomes, Human, Pair 14
Male
congenital, hereditary, and neonatal diseases and abnormalities
Adolescent
Chromosomes, Human, Pair 21
Nerve Tissue Proteins
Oligodendrocyte Transcription Factor 2
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Prognosis
Translocation, Genetic
Chromosome Banding
Fatal Outcome
hemic and lymphatic diseases
Antineoplastic Combined Chemotherapy Protocols
Basic Helix-Loop-Helix Transcription Factors
Humans
In Situ Hybridization, Fluorescence
Research Article
Subjects
Details
- ISSN :
- 17906245
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cancer genomicsproteomics
- Accession number :
- edsair.pmid..........39374281eee224b7f16dc541f9f9b26a