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Differential gene expression patterns between smokers and non‐smokers: cause or consequence?
- Source :
- Addiction Biology
- Publication Year :
- 2015
- Publisher :
- John Wiley and Sons Inc., 2015.
-
Abstract
- The molecular mechanisms causing smoking‐induced health decline are largely unknown. To elucidate the molecular pathways involved in cause and consequences of smoking behavior, we conducted a genome‐wide gene expression study in peripheral blood samples targeting 18 238 genes. Data of 743 smokers, 1686 never smokers and 890 ex‐smokers were available from two population‐based cohorts from the Netherlands. In addition, data of 56 monozygotic twin pairs discordant for ever smoking were used. One hundred thirty‐two genes were differentially expressed between current smokers and never smokers (P
- Subjects :
- Human Genetic Study
Adult
Male
Membrane Glycoproteins
Receptors, Peptide
Receptors, Retinoic Acid
Membrane Proteins
genome wide
Twins, Monozygotic
Middle Aged
smoking
Neoplasm Proteins
Receptors, G-Protein-Coupled
Case-Control Studies
gene expression
Tobacco Smoking
Humans
Female
Human Genetic Studies
Transcriptome
Subjects
Details
- Language :
- English
- ISSN :
- 13691600 and 13556215
- Volume :
- 22
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Addiction Biology
- Accession number :
- edsair.pmid..........38358b2d5af02eca7d819866cc0ae29e