Expression of R-Spondin 1 in Apc

Mutations in the APC gene and other genes in the Wnt signaling pathway contribute to development of colorectal carcinomas. R-spondins (RSPOs) are secreted proteins that amplify Wnt signaling in intestinal stem cells. Alterations in RSPO genes have been identified in human colorectal tumors. We studied the effects of RSPO1 overexpression in ApcAn adeno associated viral vector encoding RSPO1-Fc fusion protein, or control vector, was injected into ApcIntestines from ApcExpression of RSPO1 in Apc