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Cellular and genetic control of antibody responses. VIII. MHC restricted recognition of accessory cells, not B cells, by parent-specific subpopulations of normal F1 T helper cells
- Source :
- Journal of immunology (Baltimore, Md. : 1950). 124(3)
- Publication Year :
- 1980
-
Abstract
- Normal F1 helper T cell populations were analyzed under conditions in which the number of T cells was strictly limiting so that anti-hapten PFC responses to TNP-KLH increased linearly with increasing numbers of T cells. The slope of the response line is a measure of the helper activity of the added T cell population and reflects the number of helper T cells activated. In this way, the recognition and activation requirements of normal F1 helper T cell subpopulations were analyzed. It was determined that the F1 helper T cells specific for recognizing antigen in the context of the MHC determinants of only one parent specifically recognized those determinants expressed on accessory cells, but not on B cells. Indeed, each parent-specific F1 T cell subpopulation was only triggered by one parent's accessory cells; but once triggered, each parent-specific F1 T cell subpopulation was capable of activating either parent's B cells.
Details
- ISSN :
- 00221767
- Volume :
- 124
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Accession number :
- edsair.pmid..........34b42f561648c898c939051800c06df1