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Acquired Von Willebrand Syndrome In Aortic Stenosis: Case Report And Review
- Source :
- Boletin de la Asociacion Medica de Puerto Rico. 107(2)
- Publication Year :
- 2015
-
Abstract
- We present a case of a 61 year old man who presented with a 3 week history of easy bruising and ecchymoses in both thighs and right arm without significant trauma. Physical exam was remarkable for oozing gums, diminished second heart sound, a systolic ejection murmur at the aortic position with radiation to carotids, and delayed pulses. Laboratories were remarkable for iron deficiency anemia. Echocardiogram was consistent with severe aortic stenosis. Colonoscopy revealed several arteriovenous malformations throughout the colon. There is an association between severe aortic stenosis and gastrointestinal bleeding. The pathogenesis of Heyde's Syndrome involves iron deficiency anemia due to acquired von Willebrand factor (vWF) deficiency and ultimately gastrointestinal angiodysplasia. Correct diagnosis and management warrants a multidisciplinary approach.
- Subjects :
- Male
Protein Stability
Ecchymosis
ADAMTS13 Protein
Aortic Valve Stenosis
Colonoscopy
Syndrome
Middle Aged
Angiodysplasia
Enzyme Activation
Treatment Refusal
ADAM Proteins
von Willebrand Diseases
Hypertension
von Willebrand Factor
Humans
Diabetic Nephropathies
Gastrointestinal Hemorrhage
Protein Structure, Quaternary
Shear Strength
Subjects
Details
- ISSN :
- 00044849
- Volume :
- 107
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Boletin de la Asociacion Medica de Puerto Rico
- Accession number :
- edsair.pmid..........33ac12a1885922ec59f9d261dfa568a5