[The receptor-dependent and non-receptor-dependent mechanism of melatonin activated BK

To investigate the mechanisms through which myocyte large-conductance CaMiddle cerebral arteries (MCA) were obtained from 8-week-old male Wistar rats after anaesthetized. Middle cerebral arterial smooth muscle cells were enzymatically isolated. Whole cell recording mode of patch clamp technique was used to measure the current density of BK① Melatonin markedly increased the whole-cell BKMelatonin mediates vasodilation of MCA through the activation of BK