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Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression
- Source :
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 35(4)
- Publication Year :
- 2015
-
Abstract
- We previously reported that perlecan, a heparan-sulfate proteoglycan (Hspg2), expressed in the synovium at the cartilage-synovial junction, is required for osteophyte formation in knee osteoarthritis. To examine the mechanism underlying this process, we examined the role of perlecan in the proliferation and differentiation of synovial mesenchymal cells (SMCs), using a recently established mouse synovial cell culture method. Primary SMCs isolated from Hspg2
- Subjects :
- Mice, Knockout
Adipogenesis
Synovial Membrane
Cell Differentiation
Core Binding Factor Alpha 1 Subunit
Mesenchymal Stem Cells
SOX9 Transcription Factor
PPAR gamma
Mice
Cartilage
Chondrocytes
Gene Expression Regulation
Osteogenesis
Animals
Female
Chondrogenesis
Cells, Cultured
Heparan Sulfate Proteoglycans
Cell Proliferation
Subjects
Details
- ISSN :
- 1554527X
- Volume :
- 35
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society
- Accession number :
- edsair.pmid..........3172ac1e29d310c175f42073013e4334