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The vault RNA of

Authors :
Nikolay G, Kolev
K Shanmugha, Rajan
Kazimierz T, Tycowski
Justin Y, Toh
Huafang, Shi
Yuling, Lei
Shulamit, Michaeli
Christian, Tschudi
Source :
The Journal of biological chemistry. 294(43)
Publication Year :
2019

Abstract

Vault RNAs, found in vault ribonucleoprotein complexes, are known to be one of many types of small noncoding RNAs (ncRNAs), but their specific function is not known. A new study identifies a small ncRNA from Trypanosome brucei as a vault RNA (vtRNA) based on sequence analysis and its association with the canonical vault component TEP1. Down-regulation of T. brucei vtRNA impairs mRNA splicing in a permeabilized cell system, suggesting new roles for these enigmatic biomolecules.

Details

ISSN :
1083351X
Volume :
294
Issue :
43
Database :
OpenAIRE
Journal :
The Journal of biological chemistry
Accession number :
edsair.pmid..........30faa8442155930cea12322df6811282