Back to Search Start Over

NH-sulfoximine: A novel pharmacological inhibitor of the mitochondrial F

Authors :
Daniela, Strobbe
Rosalba, Pecorari
Oriana, Conte
Antonella, Minutolo
Christine M M, Hendriks
Stefan, Wiezorek
Danilo, Faccenda
Rosella, Abeti
Carla, Montesano
Carsten, Bolm
Michelangelo, Campanella
Source :
British journal of pharmacology. 178(2)
Publication Year :
2019

Abstract

The mitochondrial FThe chemical structure of the FNHS selectively blocks the consumption of ATP by mitochondria leading a subtle cytotoxicity associated via the concomitant engagement of autophagy which impairs cell viability. NHS achieves such a function independently of the FThe novel sulfoximine analogue of BTB-06584, NHS, acts as a selective pharmacological inhibitor of the mitochondrial F

Details

ISSN :
14765381
Volume :
178
Issue :
2
Database :
OpenAIRE
Journal :
British journal of pharmacology
Accession number :
edsair.pmid..........301f0774a06b54fa5bb1a3056fe01950