The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT

Authors :: Fabio, Del Bello
Alessandro, Bonifazi
Mario, Giannella
Gianfabio, Giorgioni
Alessandro, Piergentili
Riccardo, Petrelli
Carlo, Cifani
Maria Vittoria, Micioni Di Bonaventura
Thomas M, Keck
Angelica, Mazzolari
Giulio, Vistoli
Antonio, Cilia
Elena, Poggesi
Rosanna, Matucci
Wilma, Quaglia
Source :: European journal of medicinal chemistry. 125
Publication Year :: 2016
Abstract: N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine (3) is a potent 5-HT

Subjects :: Dioxanes
Molecular Docking Simulation
Mice
Structure-Activity Relationship
Anti-Anxiety Agents
Receptors, Adrenergic, alpha-1
Receptor, Serotonin, 5-HT1A
Ethylamines
Animals
Amines
Anxiety
Ligands
Retrospective Studies

Tools