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Clinical efficacy of atezolizumab plus bevacizumab and chemotherapy in
- Source :
- Journal for immunotherapy of cancer. 10(2)
- Publication Year :
- 2021
-
Abstract
- The efficacy of atezolizumab (A) and/or bevacizumab (B) with carboplatin/paclitaxel (CP) chemotherapy was explored in the phase III, randomized IMpower150 study in patients with non-squamous non-small cell lung cancer (NSCLC) according toMutation status was determined by circulating tumor DNA next-generation sequencing. Overall survival (OS) and progression-free survival (PFS) were analyzed in a mutation-evaluable intention-to-treat population (MEP; n=920) and SP263 (programmed cell death ligand 1 (PD-L1)) biomarker-evaluable population (n=774).Within the mThese analyses support previous findings of mutation of
- Subjects :
- Adult
Kelch-Like ECH-Associated Protein 1
Lung Neoplasms
Middle Aged
Antibodies, Monoclonal, Humanized
Prognosis
Progression-Free Survival
Bevacizumab
AMP-Activated Protein Kinase Kinases
Carcinoma, Non-Small-Cell Lung
Antineoplastic Combined Chemotherapy Protocols
Mutation
Humans
Female
Tumor Suppressor Protein p53
Retrospective Studies
Subjects
Details
- ISSN :
- 20511426
- Volume :
- 10
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal for immunotherapy of cancer
- Accession number :
- edsair.pmid..........2ede524549d5f67235e2fbf42af15aa3