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Hyperthermia-induced apoptosis occurs both in a p53 gene-dependent and -independent manner in three human gastric carcinoma cell lines

Authors :
A, Goto
K, Shomori
T, Ohkumo
F, Tanaka
K, Sato
H, Ito
Source :
Oncology reports. 6(2)
Publication Year :
1999

Abstract

We examined the role of the p53 gene in hyperthermia-induced apoptosis using three human gastric carcinoma cell lines, MKN-28 (carrying mutated type p53 gene), MKN-74 (wild-type), and KATO-III (complete deletion). The results indicate that i) long-term hyperthermia causes necrosis, and short-term treatment induces apoptosis in a gradual time dependent fashion, ii) hyperthermia-triggered apoptosis can occur both in a p53 gene-dependent and -independent manner, and iii) up-regulation of Hsp70 might enhance the function of wild-type p53 protein in hyperthermia-induced apoptosis.

Details

ISSN :
1021335X
Volume :
6
Issue :
2
Database :
OpenAIRE
Journal :
Oncology reports
Accession number :
edsair.pmid..........2e792110fa06ef26890eacff9ac73052