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[Do vasodilators help in chronic heart failure?]
- Source :
- Wiener klinische Wochenschrift. 99(5)
- Publication Year :
- 1987
-
Abstract
- The value of vasodilator drugs in the treatment of patients with chronic congestive heart failure is reviewed on the basis of the randomized double-blind, placebo-controlled trials so far published. Apparently, venous, or combined venous and arteriolar dilation in addition to cardiac glycosides and diuretics may produce long-term improvement in advanced stages of heart failure. Vasodilators with isolated afterload reducing properties seem to be of limited value. Long-term improvement with nitrates and alpha-receptor blocking agents is often modest, probably due to development of tolerance. The most striking results were observed with converting enzyme inhibitors: they evoke virtually no tolerance, improve haemodynamics at rest and during exercise, relieve symptoms of heart failure and are even suggested to reduce mortality.
Details
- Language :
- German
- ISSN :
- 00435325
- Volume :
- 99
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Wiener klinische Wochenschrift
- Accession number :
- edsair.pmid..........2d4d70f6db56d8ede842c4144f3c525a