Novel Antiplasmodial Compounds Leveraged with Multistage Potency against the Parasite

Authors :: Neha, Sharma
Mohammad, Kashif
Vigyasa, Singh
Diana, Fontinha
Budhaditya, Mukherjee
Dhruv, Kumar
Shailja, Singh
Miguel, Prudencio
Agam P, Singh
Brijesh, Rathi
Source :: Journal of medicinal chemistry. 64(12)
Publication Year :: 2021
Abstract: Hydroxyethylamine (HEA)-based novel compounds were synthesized and their activity against

Subjects :: Membrane Potential, Mitochondrial
Mice, Inbred BALB C
Molecular Structure
Plasmodium berghei
Plasmodium falciparum
Molecular Dynamics Simulation
Piperazines
Malaria
Mitochondria
Mice, Inbred C57BL
Molecular Docking Simulation
Antimalarials
Structure-Activity Relationship
Parasitic Sensitivity Tests
Ethanolamines
Animals
Aspartic Acid Endopeptidases
Protein Binding

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