[The action of precursors of noradrenaline synthesis on the membrane receptors of the spinal neurons in the chick embryo]

Effect of noradrenaline precursors (L-alanine, L-phenylalanine, L-tyrosine, L-DOPA and dopamine) on glycine and NMDA receptors of freshly isolated spinal neurones of chick embryo were investigated by means of the whole cell patch-clamp and concentration clamp techniques. L-alanine and L-DOPA were found to be glycine agonists which can potentiate NMDA responses. L-tyrosine does not activate glycine receptor but potentiate NMDA one. L-phenylalanine and dopamine do not interact with both glycine and NMDA receptors.