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[Active surveillance in prostate cancer: Assessment of MRI in the selection and follow-up of patients]

Authors :
A, Raichi
G, Marcq
J-C, Fantoni
P, Puech
A, Villers
A, Ouzzane
Source :
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 28(8-9)
Publication Year :
2017

Abstract

To evaluate the contribution of multiparametric MRI (MRI) and targeted biopsies (TB) in the selection and follow-up of patients under active surveillance (AS).A single-center, retrospective cohort study on 131 patients in AS, with following criteria:≤cT2 stage, PSA≤15ng/mL, Gleason score≤6,≤3 positive biopsies and maximum tumor length≤5mm. Patients' selection and follow-up was performed by the combination of systemic biopsies (SB) and mpMRI±TB. Reclassification was defined by a Gleason score6 and/or a maximum tumor length5mm.Overall, 29 patients (22.1 %) were reclassified. Reclassification free survival rate was 93 % and 70 % at 1 year and 4 years respectively. Reclassification independent risk factors were: PSA density0.15ng/mL/cmFor patients under AS, mpMRI decreases reclassification rates over time through better initial detection of significant cancers. Its high NPV makes it an efficient monitoring tool to distinguish patients with low risk of reclassification.4.

Details

Language :
French
ISSN :
11667087
Volume :
28
Issue :
8-9
Database :
OpenAIRE
Journal :
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie
Accession number :
edsair.pmid..........28f475cf21588bd3a5abe5d83584b335