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Characterizing the multiple roles of FGF-2 in SOD1
- Source :
- Journal of cellular physiology. 234(5)
- Publication Year :
- 2018
-
Abstract
- We have previously shown that knockout of fibroblast growth factor-2 (FGF-2) and potential compensatory effects of other growth factors result in amelioration of disease symptoms in a transgenic mouse model of amyotrophic lateral sclerosis (ALS). ALS is a rapidly progressive neurological disorder leading to degeneration of cortical, brain stem, and spinal motor neurons followed by subsequent denervation and muscle wasting. Mutations in the superoxide dismutase 1 (SOD1) gene are responsible for approximately 20% of familial ALS cases and SOD1 mutant mice still are among the models best mimicking clinical and neuropathological characteristics of ALS. The aim of the present study was a thorough characterization of FGF-2 and other growth factors and signaling effectors in vivo in the SOD1
- Subjects :
- Mice, Knockout
Motor Neurons
Cell Death
Amyotrophic Lateral Sclerosis
Gene Expression Regulation, Developmental
Enzyme Activation
Mice, Inbred C57BL
Disease Models, Animal
Superoxide Dismutase-1
Astrocytes
Mutation
Animals
Fibroblast Growth Factor 2
Extracellular Signal-Regulated MAP Kinases
Muscle, Skeletal
Proto-Oncogene Proteins c-akt
Cells, Cultured
Signal Transduction
Subjects
Details
- ISSN :
- 10974652
- Volume :
- 234
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of cellular physiology
- Accession number :
- edsair.pmid..........2509f6921fc7f87d2a30613751312d0c