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Expression profile and structural divergence of novel human annexin 31
- Source :
- FEBS letters. 434(3)
- Publication Year :
- 1998
-
Abstract
- Systematic analysis of expressed sequence tags in dbEST yielded an expression profile of the ten known human annexins and led to the discovery of a novel subfamily expressed mainly in differentiating tissues. Full-length cDNAs encoded a 338-amino acid protein with less than 40% identity to other annexins, an atypical amino acid composition, and an insertion and deletion in internal repeat 3. The most striking feature was a complete ablation of all four type II calcium-binding sites in the conserved tetrad core. Annexin 31 thus constitutes a unique, natural probe for investigating the role of membrane binding in annexin function.
Details
- ISSN :
- 00145793
- Volume :
- 434
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- FEBS letters
- Accession number :
- edsair.pmid..........223db79a148ebbb1552a715b60b4be0c