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Factor VIII-Fc Activates Natural Killer Cells
- Source :
- Frontiers in Immunology
- Publication Year :
- 2021
-
Abstract
- The most challenging complication associated with Factor VIII (FVIII) replacement therapy is the development of neutralizing anti-drug antibodies, or inhibitors, which occur in 23-35% of severe (FVIII level
- Subjects :
- Fc-fusion
B-Lymphocytes
Factor VIII
natural killer cells
Recombinant Fusion Proteins
Receptors, IgG
Immunology
immunogenicity
GPI-Linked Proteins
Cell Degranulation
Hemostatics
Immunoglobulin Fc Fragments
Killer Cells, Natural
Interferon-gamma
hemic and lymphatic diseases
Fc gamma receptors
Immune Tolerance
Humans
Original Research
antibody-dependent cellular cytotoxicity
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in immunology
- Accession number :
- edsair.pmid..........2152f6f7e18201db95585f798e4faeb4