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Specialization of the photoreceptor transcriptome by
- Source :
- Proceedings of the National Academy of Sciences of the United States of America. 119(29)
- Publication Year :
- 2023
-
Abstract
- Retinal photoreceptors have a distinct transcriptomic profile compared to other neuronal subtypes, likely reflecting their unique cellular morphology and function in the detection of light stimuli by way of the ciliary outer segment. We discovered a layer of this molecular specialization by revealing that the vertebrate retina expresses the largest number of tissue-enriched microexons of all tissue types. A subset of these microexons is included exclusively in photoreceptor transcripts, particularly in genes involved in cilia biogenesis and vesicle-mediated transport. This microexon program is regulated by
Details
- ISSN :
- 10916490
- Volume :
- 119
- Issue :
- 29
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Accession number :
- edsair.pmid..........20d26c4067477c5ebe55c3d0389c5599