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Primary Fallopian Tube Carcinoma: A Single-Institution Experience of 101 Cases: A Retrospective Study
- Source :
- International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 26(3)
- Publication Year :
- 2016
-
Abstract
- This study aimed to identify the prognostic factors for primary fallopian tube carcinoma.A retrospective analysis was conducted of the patients treated with primary surgery and adjuvant chemotherapy at the Obstetrics and Gynecology Hospital of Fudan University from February 2003 to December 2010. Cox proportional hazards model was used for univariate and multivariate survival analysis.Included in this study were 101 patients with a median follow-up of 64 months and a mean age of 57 years. Latzko triad symptom of abdominal pain, vaginal bleeding or discharge, and palpable pelvic mass was reported in 14 patients, and elevated CA 125 (≥ 35 U/mL) was found in 63. Four patients were classified as grade 1, 31 were grade 2, and 66 were grade 3. The distribution of International Federation of Gynecology and Obstetrics stage was 33 at stage I, 28 at stage II, 39 at stage III, and 1 at stage IV. Ninety patients underwent optimal tumor debulking in which residual tumor was no larger than 1 cm, and 67 patients received no fewer than 6 cycles of postoperative chemotherapy with paclitaxel and carboplatin (TP)-based regimen. Recurrence occurred in 44 patients after a median of 20 months (range, 1-72 months). The 5-year overall survival rate was 67.7%, and the 5-year disease-free survival was 57.4%. Multivariate analysis revealed that International Federation of Gynecology and Obstetrics stage (I-II) [hazard ratio (HR), 2.670; 95% confidence interval (CI), 1.316-5.418; P = 0.007 vs HR, 2.716; 95% CI, 1.416-5.211; P = 0.003], pelvic lymphadenectomy (HR, 0.274; 95% CI, 0.136-0.555; P0.001 vs HR, 0.449; 95% CI, 0.227-0.888; P = 0.021), and cycles (≥ 6) of chemotherapy (HR, 0.480; 95% CI, 0.246-0.937; P = 0.031 vs HR, 0.521; 95% CI, 0.276-0.985; P = 0.045) might serve as independent predictors of both overall survival and disease-free survival.Preoperative diagnosis of fallopian tube carcinoma is difficult due to the silent course of this neoplasm. Comprehensive surgical staging including pelvic lymphadenectomy followed by adequate cycles of chemotherapy is an important strategy to improve patients' prognosis.
- Subjects :
- Adult
Aged, 80 and over
Middle Aged
Prognosis
Combined Modality Therapy
Cystadenocarcinoma, Serous
Endometrial Neoplasms
Survival Rate
Fallopian Tube Neoplasms
Humans
Female
Neoplasm Invasiveness
Neoplasm Grading
Neoplasm Recurrence, Local
Adenocarcinoma, Clear Cell
Aged
Follow-Up Studies
Neoplasm Staging
Retrospective Studies
Subjects
Details
- ISSN :
- 15251438
- Volume :
- 26
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
- Accession number :
- edsair.pmid..........1e8475b8671af3c57ff908671e9e8de7