Discovery of (

Authors :: Guanglin, Luo
Ling, Chen
Walter A, Kostich
Brian, Hamman
Jason, Allen
Amy, Easton
Clotilde, Bourin
Michael, Gulianello
Jonathan, Lippy
Susheel, Nara
Tarun Kumar, Maishal
Kamalraj, Thiyagarajan
Prasadrao, Jalagam
Sreenivasulu Naidu, Pattipati
Kumaran, Dandapani
Manoj, Dokania
Pradeep, Vattikundala
Vivek, Sharma
Saravanan, Elavazhagan
Manoj Kumar, Verma
Manish Lal, Das
Santosh, Wagh
Anand, Balakrishnan
Benjamin M, Johnson
Kenneth S, Santone
George, Thalody
Rex, Denton
Hariharan, Saminathan
Vinay K, Holenarsipur
Anoop, Kumar
Abhijith, Rao
Siva Prasad, Putlur
Sarat Kumar, Sarvasiddhi
Ganesh, Shankar
Justin V, Louis
Manjunath, Ramarao
Charles M, Conway
Yu-Wen, Li
Rick, Pieschl
Yuan, Tian
Yang, Hong
Jonathan, Ditta
Arvind, Mathur
Jianqing, Li
Daniel, Smith
Joseph, Pawluczyk
Dawn, Sun
Shiuhang, Yip
Dauh-Rurng, Wu
Muthalagu, Vetrichelvan
Anuradha, Gupta
Alan, Wilson
Suma, Gopinathan
Suman, Wason
Linda, Bristow
Charles F, Albright
Joanne J, Bronson
John E, Macor
Carolyn D, Dzierba
Source :: Journal of medicinal chemistry. 65(6)
Publication Year :: 2022
Abstract: Recent mouse knockout studies identified adapter protein-2 associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. Potent small-molecule inhibitors of AAK1 have been identified and show efficacy in various rodent pain models. (

Subjects :: Mice
Spinal Cord
Animals
Brain
Neuralgia
Amines
Protein Kinase Inhibitors
Rats

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