[Regional changes in the activity of the angiotensin-converting enzyme in the brain of rats with developing hereditarily induced hypertension]

Angiotensin-converting enzyme (ACE) activity in the pituitary zone and 7 other brain areas has been studied in rats with developing spontaneous hereditary hypertension. ACE activity was significantly different in normotensive and spontaneously hypertensive rats, with the differences most prominent in pituitary body, cerebellum, striatum and medulla oblongata. Age-dependent variability in ACE activity was demonstrated.