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Active thymopoiesis in idiopathic chronic pancreatitis
- Source :
- European review for medical and pharmacological sciences. 12(1)
- Publication Year :
- 2008
-
Abstract
- Cellular immunity has a pivotal role in the pathogenesis of chronic pancreatitis (CP), resulting in pancreas infiltration by T-cells. Studies on systemic immunity are few and contradictory. One study reported a decrease of naive CD45RA+ cells. The presence of naive T cells, detected as recent thymic emigrants (RTEs), is evaluated with a new molecular technique by using real-time PCR to detect the T-cell receptor excision circles (TREC). To elucidate the role of naive T-cells in the pathogenesis of CP, we investigated the percentage of sj-TREC in CP patients.Thirty CP patients were studied and compared to 30 sex- and age-matched healthy volunteers.Genomic DNA was isolated from peripheral blood mononuclear cells (PBMC) of each patient. RTEs were evaluated by measuring sj-TREC by real-time PCR.The mean percentage of sj-TREC+ cells present in CP was not significantly different from that of control group (0.02319% vs 0.02338%, respectively).Our data show that naive TREC+ cells are normally represented in CP. The presence of active thymopoiesis may be the underlying mechanism resulting in continuous production of T-cells, responsible of maintaining the inflammatory process.
Details
- ISSN :
- 11283602
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European review for medical and pharmacological sciences
- Accession number :
- edsair.pmid..........1dadc4a7479a43841213fbb93f4e69ec