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Secretory Carcinoma of the Salivary Gland: A Rarity in Children

Authors :
Gillean A, Kelly
Rajkumar, Venkatramani
Norma M, Quintanilla
Daniel C, Chelius
Angshumoy, Roy
Priya, Mahajan
Source :
Journal of pediatric hematology/oncology. 44(4)
Publication Year :
2021

Abstract

Originally described as mammary analog secretory carcinoma (SC), SC of the salivary gland is a rare malignancy with morphologic and molecular similarities to SC of the breast. We present 2 children with salivary gland SC with the classic ETV6-NTRK3 gene fusion, including 1 with lymph node metastases. Both patients underwent surgical resection and were in remission 24 months postsurgery. One patient was additionally found to have synchronous papillary thyroid carcinoma with a TFG-MET fusion. A review of published cases highlights the expanding molecular profile and confirms the favorable course of salivary gland SC after surgical resection.

Details

ISSN :
15363678
Volume :
44
Issue :
4
Database :
OpenAIRE
Journal :
Journal of pediatric hematology/oncology
Accession number :
edsair.pmid..........1c9cde8b0f638c4d1e05eb27b5d84c55