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Plasma Gelsolin Inhibits CD8
- Source :
- Cancer research. 80(18)
- Publication Year :
- 2020
-
Abstract
- Although initial treatment of ovarian cancer is successful, tumors typically relapse and become resistant to treatment. Because of poor infiltration of effector T cells, patients are mostly unresponsive to immunotherapy. Plasma gelsolin (pGSN) is transported by exosomes (small extracellular vesicle, sEV) and plays a key role in ovarian cancer chemoresistance, yet little is known about its role in immunosurveillance. Here, we report the immunomodulatory roles of sEV-pGSN in ovarian cancer chemoresistance. In chemosensitive conditions, secretion of sEV-pGSN was low, allowing for optimal CD8
- Subjects :
- Adult
Aged, 80 and over
Ovarian Neoplasms
NF-E2-Related Factor 2
Antineoplastic Agents
Apoptosis
CD8-Positive T-Lymphocytes
Middle Aged
Exosomes
Glutathione
Neoplasm Proteins
Immunomodulation
Interferon-gamma
STAT1 Transcription Factor
Drug Resistance, Neoplasm
Humans
Female
Cisplatin
Phosphorylation
Immunologic Surveillance
Gelsolin
Aged
Subjects
Details
- ISSN :
- 15387445
- Volume :
- 80
- Issue :
- 18
- Database :
- OpenAIRE
- Journal :
- Cancer research
- Accession number :
- edsair.pmid..........1a4a6e7e0287b0e364c7a2b202468357