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Plasma Gelsolin Inhibits CD8

Authors :
Meshach, Asare-Werehene
Laudine, Communal
Euridice, Carmona
Youngjin, Han
Yong Sang, Song
Dylan, Burger
Anne-Marie, Mes-Masson
Benjamin K, Tsang
Source :
Cancer research. 80(18)
Publication Year :
2020

Abstract

Although initial treatment of ovarian cancer is successful, tumors typically relapse and become resistant to treatment. Because of poor infiltration of effector T cells, patients are mostly unresponsive to immunotherapy. Plasma gelsolin (pGSN) is transported by exosomes (small extracellular vesicle, sEV) and plays a key role in ovarian cancer chemoresistance, yet little is known about its role in immunosurveillance. Here, we report the immunomodulatory roles of sEV-pGSN in ovarian cancer chemoresistance. In chemosensitive conditions, secretion of sEV-pGSN was low, allowing for optimal CD8

Details

ISSN :
15387445
Volume :
80
Issue :
18
Database :
OpenAIRE
Journal :
Cancer research
Accession number :
edsair.pmid..........1a4a6e7e0287b0e364c7a2b202468357