Rational design of new multitarget histamine H

Authors :: Dorota, Łażewska
Marek, Bajda
Maria, Kaleta
Paula, Zaręba
Agata, Doroz-Płonka
Agata, Siwek
Alaa, Alachkar
Szczepan, Mogilski
Ali, Saad
Kamil, Kuder
Agnieszka, Olejarz-Maciej
Justyna, Godyń
Dorota, Stary
Sylwia, Sudoł
Małgorzata, Więcek
Gniewomir, Latacz
Maria, Walczak
Jadwiga, Handzlik
Bassem, Sadek
Barbara, Malawska
Katarzyna, Kieć-Kononowicz
Source :: European journal of medicinal chemistry. 207
Publication Year :: 2020
Abstract: Design and development of multitarget-directed ligands (MTDLs) has become a very important approach in the search of new therapies for Alzheimer's disease (AD). In our present research, a number of xanthone derivatives were first designed using a pharmacophore model for histamine H

Subjects :: Male
Molecular Docking Simulation
Mice
Monoamine Oxidase Inhibitors
Alzheimer Disease
Protein Conformation
Drug Design
Animals
Humans
Receptors, Histamine H3
Cholinesterase Inhibitors
Molecular Targeted Therapy
Ligands

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