[Role of various hormones of total metabolic action in the expression of sex differentiation of the rat liver by a specific estrogen-binding protein]

The effect of some hormones of total metabolic action on a degree of sex differentiation of the liver by a specific estrogen-binding protein (SEBP) was investigated. Insulin administration did not change the SEBP level of the male rat liver. Adrenalectomy and dexamethasone administration caused no significant changes of sex differentiation of the SEBP level in the male and female rat liver. Neither did thyroidectomy cause significant changes in the SEBP level. Dose-related T3 administration decreased reversibly the SEBP level in the liver of adult male rats. The effect of T3 on the SEBP level was preserved after castration or hypophysectomy of males. T3 administration decreased a degree of determination of a raised level of SEBP in the female rat liver by androgens. STH injections were effective mainly in hypophysectomized male rats resulting, on the one hand, in an increase in the level of SEBP and creating conditions, on the other hand, for a decrease in its level caused by estradiol. It has been concluded that thyroid hormones and STH are able to be modulators of adaptive changes of sex differences of the liver by SEBP.