[Effects of taurine enhancement of synthesis of TxA2 and PGI2 in cultured intra-pulmonary arteriolar smooth muscle cells under acute hypoxia]

The results of the present study demonstrated that the concentrations of thromboxane B2 (TxB2a) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), and their ratio were significantly increased in the medium of intra-pulmonary arteriolar smooth muscle cells (PASMCs) under acute hypoxia. Under either normoxia or hypoxia the concentration of TxB2 was significantly decreased with addition of taurine, while that of 6-keto-PGF1 alpha was significantly increased. With the addition of indomethacin, however, under similar conditions, the concentrations of both TxB2 and 6-keto-PGF1 alpha were decreased. Furthermore, the effect of indomethacin on TxA2 and 6-keto-PGF1 alpha concentrations could be reversed by taurine.