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Dendritic spine actin dynamics in neuronal maturation and synaptic plasticity
- Source :
- Cytoskeleton (Hoboken, N.J.). 73(9)
- Publication Year :
- 2015
-
Abstract
- The majority of the postsynaptic terminals of excitatory synapses in the central nervous system exist on small bulbous structures on dendrites known as dendritic spines. The actin cytoskeleton is a structural element underlying the proper development and morphology of dendritic spines. Synaptic activity patterns rapidly change actin dynamics, leading to morphological changes in dendritic spines. In this mini-review, we will discuss recent findings on neuronal maturation and synaptic plasticity-induced changes in the dendritic spine actin cytoskeleton. We propose that actin dynamics in dendritic spines decrease through actin filament crosslinking during neuronal maturation. In long-term potentiation, we evaluate the model of fast breakdown of actin filaments through severing and rebuilding through polymerization and later stabilization through crosslinking. We will discuss the role of Ca(2+) in long-term depression, and suggest that actin filaments are dissolved through actin filament severing. © 2016 Wiley Periodicals, Inc.
Details
- ISSN :
- 19493592
- Volume :
- 73
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Cytoskeleton (Hoboken, N.J.)
- Accession number :
- edsair.pmid..........173bcf25c3f0358f154aaae087c4aa4c