[Sepsis. The fundamentals of the therapeutic program development]

The more than ten-year experience of treatment of 287 patients with sepsis, caused by severe surgical disease of the soft tissues, was summarized. Algorithm of therapeutic program was proposed. Necessity of specialized hospitals organization was substantiated. Was paid attention on importance of early diagnosis of sepsis, full value treatment of primary focus of infection and conduction of therapy, based on principles of evidence-based medicine.