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Angiopoietin-like Protein 2 as a Predictor of Early Recurrence in Patients After Curative Surgery for Gastric Cancer
- Source :
- Anticancer research. 35(9)
- Publication Year :
- 2015
-
Abstract
- Angiopoietin-like protein-2 (ANGPTL2) mediates chronic inflammation. Tumor cell-derived ANGPTL2 promotes tumor invasion and angiogenesis. ANGPTL2 expression has not been fully investigated in gastric cancer (GC).ANGPTL2 expression in 354 patients with GC was assessed by immunohistochemistry (IHC). IHC scores were calculated, and the association of ANGPTL2 with clinicopathological factors and patient outcomes was evaluated.Immunoreactive ANGPTL2 protein was expressed mainly in GC cell cytoplasm. Kaplan-Meier analysis showed that high expression of ANGPTL2 indicated significantly poorer overall disease-free survival (DFS). Among patients with curatively resected GC, multivariate analysis for DFS revealed that high ANGPTL2 expression (p0.01), advanced T-stage (p=0.015), lymph node metastasis (p0.01), and advanced Unio Internationalis Contra Cancrum (UICC) stage (p0.01) were independent risk factors for poor DFS.High cytoplasmic ANGPTL2 expression in GC tissue was associated with tumor progression, invasion, metastasis, and poor prognosis. ANGPTL2 may be a useful marker for detecting early postoperative recurrence in patients with GC.
- Subjects :
- Adult
Aged, 80 and over
Male
Adolescent
Kaplan-Meier Estimate
Middle Aged
Prognosis
Immunohistochemistry
Disease-Free Survival
Young Adult
Angiopoietin-like Proteins
Gastric Mucosa
Stomach Neoplasms
Multivariate Analysis
Disease Progression
Humans
Female
Neoplasm Recurrence, Local
Angiopoietins
Angiopoietin-Like Protein 2
Aged
Subjects
Details
- ISSN :
- 17917530
- Volume :
- 35
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Anticancer research
- Accession number :
- edsair.pmid..........13af05b7dddd4ce8113a0ef333f29446