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Rational synthesis of three-dimensional core–double shell upconversion nanodendrites with ultrabright luminescence for bioimaging application† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc01586h
- Source :
- Chemical Science
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry, 2019.
-
Abstract
- Herein, we rationally fabricated three-dimensional upconversion core–double shell nanodendrites as efficient and safe luminescent probes for in vitro and in vivo bioimaging.<br />Engineering the morphology of rare-earth doped NaYF4-based upconversion nanoparticles (UCNPs) can effectively tune their upconversion luminescence emission (UCLE) properties. Herein, we rationally synthesized a new class of three-dimensional upconversion core–double-shell nanodendrites (UCNDs) including an active core (NaYF4:Yb,Er,Ca) capped by a transition layer (NaYF4:Yb,Ca) and an active outer shell (NaNdF4:Yb,Ca). The high concentration of the Nd3+ sensitizer in the outer dendritic shell enhances the luminescence intensity, while the transition layer enriched with Yb3+ acts as an efficient energy migration network between the outer shell and inner core along with preventing the undesired quenching effects resulting from Nd3+. These unique structural and compositional merits enhanced the UCLE of UCNDs by 5 and 15 times relative to NaYF4:Yb,Er,Ca@NaYF4:Yb,Ca truncated core–shell UCNPs and NaYF4:Yb,Er,Ca spherical core UCNPs, respectively, under excitation at 980 nm. The SiO2–COOH layer coated UCNDs (UCND@SiO2–COOH) were successfully used as efficient long-term luminescent probes for in vitro and in vivo bioimaging without any significant toxicity. The uptake and retention of UCND@SiO2–COOH were mostly found in the liver and spleen. This study may open the way towards the preparation of three-dimensional UCND nanostructures for biomedical applications.
- Subjects :
- Chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 20416539 and 20416520
- Volume :
- 10
- Issue :
- 32
- Database :
- OpenAIRE
- Journal :
- Chemical Science
- Accession number :
- edsair.pmid..........12467f1b4933ba00b8f41716ebb2451a