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Effect of early administration of lower dose versus high dose of fresh mitochondria on reducing monocrotaline-induced pulmonary artery hypertension in rat
- Source :
- American journal of translational research. 8(12)
- Publication Year :
- 2015
-
Abstract
- Objective: This study aim to investigate whether early mitochondrial administration would be effective and whether high-dose mitochondria (15000 μg/rat) would be more effective than low-dose mitochondria (1500 μg/rat) for attenuating the monocrotaline (MCT/65 mg/kg/rat)-induced pulmonary artery hypertension (PAH) in rat. Method and results: Male-adult SD rats (n = 32) were randomized categorized into groups 1 (sham-control), 2 (PAH), 3 (PAH + low-dose mitochondria), and 4 (PAH + high-dose mitochondria). Mitochondria were admitted at day 5 and rats were sacrificed at day 35 post-MCT treatment. By day 35, oxygen saturation (saO2) was highest in group 1 and lowest in group 2, and significantly higher in group 3 than in group 4 (P
- Subjects :
- Original Article
Subjects
Details
- ISSN :
- 19438141
- Volume :
- 8
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- American journal of translational research
- Accession number :
- edsair.pmid..........116d69b7615e023532e359b90b50b318