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Cancer immunotherapy via targeted TGF-β signalling blockade in T
- Source :
- Nature. 587(7832)
- Publication Year :
- 2019
-
Abstract
- Cancer arises from malignant cells that exist in dynamic multilevel interactions with the host tissue. Cancer therapies aiming to directly kill cancer cells, including oncogene-targeted therapy and immune-checkpoint therapy that revives tumour-reactive cytotoxic T lymphocytes, are effective in some patients
- Subjects :
- Male
Vascular Endothelial Growth Factor A
Cell Death
Receptor, Transforming Growth Factor-beta Type II
Antibodies, Monoclonal
Breast Neoplasms
T-Lymphocytes, Helper-Inducer
Cell Hypoxia
Mice
HEK293 Cells
Transforming Growth Factor beta
Cell Line, Tumor
Animals
Humans
Female
Immunotherapy
Interleukin-4
Lymph Nodes
Signal Transduction
Subjects
Details
- ISSN :
- 14764687
- Volume :
- 587
- Issue :
- 7832
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.pmid..........0f8dbce38e047a482b2d443552784bdb