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Treatment of Papillon-Lefèvre syndrome periodontitis
- Source :
- Journal of clinical periodontology. 29(4)
- Publication Year :
- 2002
-
Abstract
- Conventional mechanical treatment of Papillon-Lefèvre syndrome periodontitis has a poor prognosis. This report describes an effective antimicrobial treatment of rapidly progressing periodontitis in an 11-year old girl having Papillon-Lefèvre syndrome.Clinical examination included conventional periodontal measurements and radiographic analysis. Occurrence of major suspected periodontopathic bacteria was determined by selective and non-selective culture and by polymerase chain reaction (PCR) identification. Presence of cytomegalovirus and Epstein-Barr type 1 virus was determined by a nested-PCR detection method. Therapy included scaling and root planing, oral hygiene instruction, and systemic amoxicillin-metronidazole therapy (250 mg of each/3 times daily/10 days) which, based on follow-up microbiological testing, was repeated after 4 months. Supportive periodontal therapy took place at 2 visits during a 16-month period.At baseline, 10 of 22 available teeth demonstrated severe periodontal breakdown. At 16 months, probing and radiographic measurements revealed no teeth with additional attachment loss, and several teeth exhibited significant reduction in gingivitis and pocket depth, increase in radiographic alveolar bone height and clinical attachment level, and radiographic evidence of crestal lamina dura. Baseline subgingival microbiota included Actinobacillus actinomycetemcomitans (3.4% of total isolates), Prevotella nigrescens (16.4%), Fusobacteriumnucleatum (14.3%) and Peptostreptococcus micros (10.6%), as well as cytomegalovirus and Epstein-Barr type 1 virus. At termination of the study, culture and PCR examinations showed absence of A. actinomycetemcomitans, P. micros and herpesviruses, and P. nigrescens and F.nucleatum each comprised less than 0.1 % of subgingival isolates.This study suggests that controlling the periodontopathic microbiota by appropriate antibiotic and conventional periodontal therapy can arrest Papillon-Lefèvre syndrome periodontitis.
- Subjects :
- Herpesvirus 4, Human
Fusobacterium nucleatum
Peptostreptococcus
Alveolar Bone Loss
Prevotella
Amoxicillin
Cytomegalovirus
Penicillins
Oral Hygiene
Prognosis
Aggregatibacter actinomycetemcomitans
Gingivitis
Anti-Bacterial Agents
Root Planing
Papillon-Lefevre Disease
Anti-Infective Agents
Metronidazole
Periodontal Attachment Loss
Dental Scaling
Humans
Periodontal Pocket
Female
Child
Periodontitis
Follow-Up Studies
Subjects
Details
- ISSN :
- 03036979
- Volume :
- 29
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of clinical periodontology
- Accession number :
- edsair.pmid..........0c7e841b857dc4cb8f6d17de9a53fb52