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[Neoadjuvant chemotherapy using TS-1 and CDDP against large type 3/Type 4/Bulky N 2 advanced gastric cancer]
- Source :
- Gan to kagaku ryoho. Cancerchemotherapy. 32(13)
- Publication Year :
- 2005
-
Abstract
- This study was conducted to assess therapeutic results following neoadjuvant chemotherapy (NAC) for large type 3/type 4/Bulky N 2 advanced gastric cancer having a poor prognosis following resection. The subjects consisted of cases (or = 75 y.o.) having large type 3 (diameteror = 8 cm), type 4 or Bulky N 2 gastric cancer curable by resection based on preoperative imaging diagnostics. The NAC regimen consisted of TS-1 at 80-120 mg/body on days 1-21 p. o. and CDDP at 60 mg/m2 on day 8 divided. Upon completion of two courses of 4 weeks per course, gastrectomy withor = D2 lymph node dissection was carried out on days 21-34. The average age of the subjects was 60.7 years, and the therapy completion rate was 80% (8/10 cases). Five of ten cases were responders diagnosed as grade 2 by histopathological examination of excised specimens (response rate 50%). Two of five responders were histopathologically evaluated as down-staging as a result of NAC (Stage III A--f Stage I A, Stage IV--f Stage I A). Three of the five non-responders have relapsed, and the relapse-free interval was an average 238 days. In the five responders,one has relapsed at 331 days,while the other 4 responders have shown no relapse yet. Although NAC consisting of TS-1 and CDDP is considered to be effective against advanced gastric cancer, a phase III study with surgical treatment only will be necessary to confirm its true value.
- Subjects :
- Male
Pyridines
Middle Aged
Survival Analysis
Drug Administration Schedule
Neoadjuvant Therapy
Drug Combinations
Oxonic Acid
Gastrectomy
Stomach Neoplasms
Lymphatic Metastasis
Antineoplastic Combined Chemotherapy Protocols
Humans
Lymph Node Excision
Female
Lymph Nodes
Cisplatin
Aged
Neoplasm Staging
Tegafur
Subjects
Details
- ISSN :
- 03850684
- Volume :
- 32
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- Gan to kagaku ryoho. Cancerchemotherapy
- Accession number :
- edsair.pmid..........0c3d1cad0086e5679db098c3e660f7e2