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BCL10 gene amplification associated with strong nuclear BCL10 expression in a diffuse large B cell lymphoma with IGH-BCL2 fusion
- Source :
- Haematologica. 91
- Publication Year :
- 2006
-
Abstract
- Cytogenetic investigation of a nodal diffuse large B cell lymphoma carrying an IGH-BCL2-fusion revealed a homogeneously staining region at chromosome 1p21-22. Fluorescence in situ hybridisation (FISH) demonstrated heterogeneous BCL10 gene amplification in tumour cells. Immunohistochemistry showed heterogeneous over-expression of the protein in the nuclei of tumour cells, similar to that seen in MALT lymphoma cells with t(1;14)(p22;q32).
- Subjects :
- Chromosomes, Human, Pair 14
Lymphoma, B-Cell
Recombinant Fusion Proteins
Gene Amplification
Chromosome Mapping
Forkhead Transcription Factors
B-Cell CLL-Lymphoma 10 Protein
Translocation, Genetic
Neoplasm Proteins
Gene Expression Regulation, Neoplastic
Repressor Proteins
Chromosomes, Human, Pair 1
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Caspases
Humans
Lymphoma, Large B-Cell, Diffuse
Immunoglobulin Heavy Chains
Adaptor Proteins, Signal Transducing
bcl-2-Associated X Protein
Subjects
Details
- ISSN :
- 15928721
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- Haematologica
- Accession number :
- edsair.pmid..........0bf087d3e379c54149fde9e0543f9c93