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BCL10 gene amplification associated with strong nuclear BCL10 expression in a diffuse large B cell lymphoma with IGH-BCL2 fusion

Authors :
Hongtao, Ye
Stefan, Gesk
Jose I, Martin-Subero
Alexander, Nader
Ming-Qing, Du
Reiner, Siebert
Source :
Haematologica. 91
Publication Year :
2006

Abstract

Cytogenetic investigation of a nodal diffuse large B cell lymphoma carrying an IGH-BCL2-fusion revealed a homogeneously staining region at chromosome 1p21-22. Fluorescence in situ hybridisation (FISH) demonstrated heterogeneous BCL10 gene amplification in tumour cells. Immunohistochemistry showed heterogeneous over-expression of the protein in the nuclei of tumour cells, similar to that seen in MALT lymphoma cells with t(1;14)(p22;q32).

Details

ISSN :
15928721
Volume :
91
Database :
OpenAIRE
Journal :
Haematologica
Accession number :
edsair.pmid..........0bf087d3e379c54149fde9e0543f9c93