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Sarcoidosis: An Occupational Disease?
- Source :
- Chest
- Publication Year :
- 2021
-
Abstract
- Sarcoidosis is an important member of the family of granulomatous lung diseases. Since its recognition in the late 19th century, sarcoidosis has been thought of as a disease of unknown cause. Over the past 20 years, this paradigm has been shifting, more rapidly in the past 10 years. Epidemiologic studies, bolstered by case reports, have provided evidence of causal associations between occupational exposure to specific agents and sarcoidosis. Pathogenesis has been more clearly defined, including the role of gene-exposure interactions. The use of in vitro lymphocyte proliferation testing to detect sensitization to inorganic antigens is being examined in patients with sarcoidosis. These antigens include silica and certain metals. Results of studies to date show differences in immunoreactivity of occupationally exposed sarcoidosis cases compared with control cases, suggesting that lymphocyte proliferation testing may prove useful in diagnosing work-related disease. This review discusses recently published findings regarding associations between occupational exposure to silica and silicates, World Trade Center dust, and metals and risk for sarcoidosis, as well as advances in the development of diagnostic tools. Not all cases of sarcoidosis have an identified cause, but some do. Where the cause is occupational, its recognition is critical to enable effective treatment through removal of the affected worker from exposure and to inform intervention aimed at primary prevention.
- Subjects :
- Sarcoidosis
Immunologic Tests
ATS, American Thoracic Society
Lymphocyte Activation
PM, particulate matter
Calcium Sulfate
CBD, chronic beryllium disease
RCS, respirable crystalline silica
Ti, titanium
Calcium Carbonate
MELISA, Memory Lymphocyte ImmunoStimulation Assay
JEM, job-exposure matrix
Sarcoidosis, Pulmonary
Occupational Exposure
World Trade Center dust
Humans
genetics
Diffuse Lung Disease: CHEST Reviews
LPT, lymphocyte proliferation test
WTC, World Trade Center
HLA, human leukocyte antigen
Silicates
Emergency Responders
lymphocyte proliferation test
Al, aluminum
SLGPD, sarcoidosis-like granulomatous pulmonary disease
Silicon Dioxide
Occupational Diseases
Metals
silica
New York City
September 11 Terrorist Attacks
NYC, New York City
Subjects
Details
- ISSN :
- 19313543
- Volume :
- 160
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Chest
- Accession number :
- edsair.pmid..........0a6b5b546d18e14ca3d64413d1b9611b